Peer to Peer Review

Publications on Protandim

2014 University of Kentucky : Dr. Joe McCord (Ph.D. 1970)

Recognized here as a Redox Pioneer because he has published at least three articles on antioxidant/redox biology as first/last author that have been cited over 1000 times and has published at least 37 articles each cited over 100 times. Dr. McCord is known for the monumental discovery of the antioxidant superoxide dismutase (SOD) while a graduate student under fellow redox pioneer Irwin Fridovich and demonstrating its necessity to aerobic life.    

2013 Colorado State University: The role of Nrf2

In the attenuation of cardiovascular disease. Exercise and various phytochemicals activate nuclear factor (erythroid-derived 2)-like 2 (Nrf2), the master regulator of antioxidant defenses, and attenuate  cardiovascular diseases.  Read E-Book

2013 Russian Academy of Medical Sciences : The redox-sensitive signaling system

Keap1/Nrf2/ARE plays a key role in maintenance of cellular homeostasis under stress, inflammatory, carcinogenic, and proapoptotic conditions, which allows us to consider it as a pharmacological target. Here we review the basic regulatory mechanisms of the Keap1/Nrf2/ARE system, key targets for pharmacological intervention, and interconnection of this system with other redox-sensitive transcriptional factors. We also discuss the range of currently available pharmaceuticals. Finally, we promote “indirect” antioxidants as a promising strategy for prevention and treatment of wide range of diseases associated with oxidative stress.

2013 Colorado State University : Nrf2 activation: a potential strategy for the prevention of acute mountain sickness. 

Of nine drugs tested, with the exception of dexamethasone, only drugs that showed the ability to activate Nrf2 (Protandim, methazolamide, nifedipine, amlodipine, ambrisentan, and sitaxentan) decreased high-altitude-induced cerebral vascular leak in vivo.  

2013 Colorado State University : Upregulation of phase II enzymes

Through phytochemical activation of Nrf2 protects cardiomyocytes against oxidant stress.Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a transcriptional regulator of phase II antioxidant enzymes, and activation of Nrf2 has been suggested to be an important step in attenuating oxidative stress associated with cardiovascular disease.

2012 University of Connecticut : Nuclear erythroid 2–related factor 2 (Nrf2) is an oxidative stress–mediated transcription factor

With a variety of downstream targets aimed at cytoprotection. Nrf2 has recently been implicated as a new therapeutic target for the treatment of liver disease. 

2012 University of Colorado : Phytochemical activation of Nrf2 protects human coronary artery endothelial cells against an oxidative challenge.

Activation of NF-E2-related factor 2 (Nrf2) is a potential therapeutic intervention against endothelial cell oxidative stress and associated vascular disease. We hypothesized that treatment with the phytochemicals in the patented dietary supplement Protandim would induce Nrf2 nuclear localization and phase II antioxidant enzyme protein in human coronary artery endothelial cells (HCAECs), protecting against an oxidant challenge in an Nrf2- dependent manner.

2012 University of Colorado : Protandim does not influence alveolar epithelial permeability or intrapulmonary oxidative stress in human subjects with alcohol use disorders

Including alcohol abuse and dependence, have been linked to the development of acute lung injury (ALI). Prior clinical investigations suggested an association between AUDs and abnormal alveolar epithelial permeability mediated through pulmonary oxidative stress thatmay partially explain this relationship.

2011 European and Americas Committees for Treatment and Research in Multiple Sclerosis Amsterdam, Netherlands

 Nrf2 activators: a novel strategy to promote oligodendrocyte survival in multiple sclerosis? Potential of different Nrf2 activators to boost antioxidant enzyme expression in oligodendrocytes and protect them from reactive oxygen species (ROS)-mediated cell death.

2011 University of Colorado : Oxidative stress in health and disease:  The therapeutic potential of Nrf2 activation.  

In the last decade our view of oxidative stress has broadened considerably, and it is now often seen as an imbalance that has its origins in our genes, and the ways in which gene expression is regulated. At the center of this new focus is the transcription factor called nuclear factor (erythroid-derived 2)-like 2, or Nrf2. Nrf2 is referred to as the “master regulator” of the antioxidant response.  Protandim is an antioxidant supplement that consists of five ingredients, namely, ashwagandha, bacopa extract, green tea extract, silymarin, and curcumin, each with known therapeutic properties. Download PDF

2011 Louisiana State University : The Role of Manganese Superoxide Dismutase in Skin Cancer. 

This method effectively reduced oxidative injury and proliferation without interfering with apoptosis. In another approach, Protandim, a combination of 5 well-studied medicinal plants, was given via dietary administration and significantly decreased tumor incidence and multiplicity by 33% and 57%, respectively. These studies suggest that alterations in antioxidant response may be a novel approach to chemoprevention.

2011 Ohio State University : Protandim attenuates intimal hyperplasia in human saphenous veins cultured ex vivo via a catalase-dependent pathway

Treatment of HSV during culture with Protandim increased the activity of SOD, HO-1, and catalase 3-, 7-, and 12-fold, respectively, and decreased the levels of superoxide (O(2)(•-)) and the lipid peroxidation product 4-HNE.

2010 University of Colorado : The Dietary Supplement Protandim Decreases Plasma Osteopontin

Improves Markers of Oxidative Stress in Muscular Dystrophy Mdx Mice.  In this study we investigated whether Protandim provided benefit using surrogate markers and functional measures in the dystrophin-deficient (mdx)mouse model of DMD. After 6 months of Protandim, a 48% average decrease in plasma TBARS was seen.

2010 Louisiana State University : The chemopreventive effects of Protandim

Modulation of p53 mitochondrial translocation and apoptosis during skin carcinogenesis. Previous studies have demonstrated that Protandim suppresses cutaneous proliferation and inflammation. Since DMBA/TPA also causes cell death, we investigated the effects of Protandim on cutaneous apoptosis. Download PDF

2009 American Heart Association : Chronic Pulmonary Artery Pressure Elevation Is Insufficient to Explain Right Heart Failure.

Pulmonary hypertension and subsequent right heart failure are increasingly being identified as worldwide problems affecting patients with highly prevalent diseases such as schistosomiasis, sickle cell disease, HIV infection, chronic obstructive pulmonary disease, and chronic left heart failure.1 Right ventricular (RV) function is the most important determinant of longevity in patients with pulmonary arterial hypertension.

2009 Louisiana State University : Protandim, a Fundamentally New Antioxidant Approach in Chemoprevention

Using Mouse Two-Stage Skin Carcinogenesis as a Model.  At the end of the carcinogenesis study both skin tumor incidence and multiplicity were reduced in the mice on the Protandim diet by 33% and 57% respectively, compared with those on basal diet.studies revealed that the Protandim diet suppressed tumor promoter-induced oxidative stress (evidenced by reduction of protein carbonyl levels). Protandim may serve as a practical and potent approach for cancer prevention.  Download PDF

2009 University of Colorado : Synergistic induction of heme oxygenase-1 by the components of the antioxidant supplement Protandim. 

Protandim is an antioxidant supplement that consists of five ingredients, namely, ashwagandha, bacopa extract, green tea extract, silymarin, and curcumin, each with known therapeutic properties.  There were significant increases in the levels of total glutathione in Protandim-treated cells. These findings suggest that the use of a combination of phytochemicals may be an efficient method for the induction of antioxidant enzymes. Download PDF

2006 University of Colorado: The induction of human superoxide dismutase and catalase in vivo

a fundamentally new approach to antioxidant therapy. five widely studied medicinal plants (Protandim) was administered to healthy human subjects ranging in age from 20 to 78 years. Download PDF

1985 University of Colorado : Oxygen-derived free radicals in postischemic tissue injury

Dysfunction induced by free radicals may thus be a major component of ischemic diseases of the heart, bowel, liver, kidney, and brain. Read Article

1970 Superoxide dismutase from escherichia coli. A new manganese-containing enzyme PMID 4921969

Superoxide dismutase, which catalyzes the disproportionation of univalently reduced oxygen (O2. + O2. + 2H+ → O2 + H2O2) and which has previously been demonstrated in a variety of mammalian sources, has now been purified from Escherichia coli.

1969 Superoxide dismutase. An enzymic function for erythrocuprein PMID 5389100

An enzyme which catalyzes the dismutation of superoxide radicals (O2·- + O2·-+ 2H+ → O2 + H2O2) has been purified by a simple procedure from bovine erythrocytes. This enzyme, called superoxide dismutase, contains 2 eq of copper per mole of enzyme. The copper may be reversibly removed, and it is required for activity.

 Read more on – Dr. McCord published studies at PubMed

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