Recognized here as a Redox Pioneer because he has published at least three articles on antioxidant/redox biology as first/last author that have been cited over 1000 times and has published at least 37 articles each cited over 100 times. Dr. McCord is known for the monumental discovery of the antioxidant superoxide dismutase (SOD) while a graduate student under fellow redox pioneer Irwin Fridovich and demonstrating its necessity to aerobic life.
In the attenuation of cardiovascular disease. Exercise and various phytochemicals activate nuclear factor (erythroid-derived 2)-like 2 (Nrf2), the master regulator of antioxidant defenses, and attenuate cardiovascular diseases. Read E-Book
Keap1/Nrf2/ARE plays a key role in maintenance of cellular homeostasis under stress, inflammatory, carcinogenic, and proapoptotic conditions, which allows us to consider it as a pharmacological target. Here we review the basic regulatory mechanisms of the Keap1/Nrf2/ARE system, key targets for pharmacological intervention, and interconnection of this system with other redox-sensitive transcriptional factors. We also discuss the range of currently available pharmaceuticals. Finally, we promote “indirect” antioxidants as a promising strategy for prevention and treatment of wide range of diseases associated with oxidative stress.
Of nine drugs tested, with the exception of dexamethasone, only drugs that showed the ability to activate Nrf2 (Protandim, methazolamide, nifedipine, amlodipine, ambrisentan, and sitaxentan) decreased high-altitude-induced cerebral vascular leak in vivo.
Through phytochemical activation of Nrf2 protects cardiomyocytes against oxidant stress.Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a transcriptional regulator of phase II antioxidant enzymes, and activation of Nrf2 has been suggested to be an important step in attenuating oxidative stress associated with cardiovascular disease.
With a variety of downstream targets aimed at cytoprotection. Nrf2 has recently been implicated as a new therapeutic target for the treatment of liver disease.
Activation of NF-E2-related factor 2 (Nrf2) is a potential therapeutic intervention against endothelial cell oxidative stress and associated vascular disease. We hypothesized that treatment with the phytochemicals in the patented dietary supplement Protandim would induce Nrf2 nuclear localization and phase II antioxidant enzyme protein in human coronary artery endothelial cells (HCAECs), protecting against an oxidant challenge in an Nrf2- dependent manner.
Including alcohol abuse and dependence, have been linked to the development of acute lung injury (ALI). Prior clinical investigations suggested an association between AUDs and abnormal alveolar epithelial permeability mediated through pulmonary oxidative stress thatmay partially explain this relationship.
Nrf2 activators: a novel strategy to promote oligodendrocyte survival in multiple sclerosis? Potential of different Nrf2 activators to boost antioxidant enzyme expression in oligodendrocytes and protect them from reactive oxygen species (ROS)-mediated cell death.
In the last decade our view of oxidative stress has broadened considerably, and it is now often seen as an imbalance that has its origins in our genes, and the ways in which gene expression is regulated. At the center of this new focus is the transcription factor called nuclear factor (erythroid-derived 2)-like 2, or Nrf2. Nrf2 is referred to as the “master regulator” of the antioxidant response. Protandim is an antioxidant supplement that consists of five ingredients, namely, ashwagandha, bacopa extract, green tea extract, silymarin, and curcumin, each with known therapeutic properties. Download PDF
This method effectively reduced oxidative injury and proliferation without interfering with apoptosis. In another approach, Protandim, a combination of 5 well-studied medicinal plants, was given via dietary administration and significantly decreased tumor incidence and multiplicity by 33% and 57%, respectively. These studies suggest that alterations in antioxidant response may be a novel approach to chemoprevention.
Treatment of HSV during culture with Protandim increased the activity of SOD, HO-1, and catalase 3-, 7-, and 12-fold, respectively, and decreased the levels of superoxide (O(2)(•-)) and the lipid peroxidation product 4-HNE.
Improves Markers of Oxidative Stress in Muscular Dystrophy Mdx Mice. In this study we investigated whether Protandim provided benefit using surrogate markers and functional measures in the dystrophin-deficient (mdx)mouse model of DMD. After 6 months of Protandim, a 48% average decrease in plasma TBARS was seen.
Modulation of p53 mitochondrial translocation and apoptosis during skin carcinogenesis. Previous studies have demonstrated that Protandim suppresses cutaneous proliferation and inflammation. Since DMBA/TPA also causes cell death, we investigated the effects of Protandim on cutaneous apoptosis. Download PDF
Pulmonary hypertension and subsequent right heart failure are increasingly being identified as worldwide problems affecting patients with highly prevalent diseases such as schistosomiasis, sickle cell disease, HIV infection, chronic obstructive pulmonary disease, and chronic left heart failure.1 Right ventricular (RV) function is the most important determinant of longevity in patients with pulmonary arterial hypertension.
Using Mouse Two-Stage Skin Carcinogenesis as a Model. At the end of the carcinogenesis study both skin tumor incidence and multiplicity were reduced in the mice on the Protandim diet by 33% and 57% respectively, compared with those on basal diet.studies revealed that the Protandim diet suppressed tumor promoter-induced oxidative stress (evidenced by reduction of protein carbonyl levels). Protandim may serve as a practical and potent approach for cancer prevention. Download PDF
Protandim is an antioxidant supplement that consists of five ingredients, namely, ashwagandha, bacopa extract, green tea extract, silymarin, and curcumin, each with known therapeutic properties. There were significant increases in the levels of total glutathione in Protandim-treated cells. These findings suggest that the use of a combination of phytochemicals may be an efficient method for the induction of antioxidant enzymes. Download PDF
a fundamentally new approach to antioxidant therapy. five widely studied medicinal plants (Protandim) was administered to healthy human subjects ranging in age from 20 to 78 years. Download PDF
Dysfunction induced by free radicals may thus be a major component of ischemic diseases of the heart, bowel, liver, kidney, and brain. Read Article
Superoxide dismutase, which catalyzes the disproportionation of univalently reduced oxygen (O2.– + O2.– + 2H+ → O2 + H2O2) and which has previously been demonstrated in a variety of mammalian sources, has now been purified from Escherichia coli.
An enzyme which catalyzes the dismutation of superoxide radicals (O2·- + O2·-+ 2H+ → O2 + H2O2) has been purified by a simple procedure from bovine erythrocytes. This enzyme, called superoxide dismutase, contains 2 eq of copper per mole of enzyme. The copper may be reversibly removed, and it is required for activity.
Read more on – Dr. McCord published studies at PubMed